Hypothetical scenario: You've sent your latest draft to two readers you trust and respect. These people are people who have proven their insight and intelligence to you time and again and have given you great ideas in the past.
A week or so later they come back with their notes. They're in sync on some points, but on one extremely critical point - could be a major turning point for the character's arc, it could be your turning point into Act Three - they are diametrically opposed. One loves everything about it, one totally hates it.
How do you decide which note to follow?